40Hz tACS in Treating Cognitive Function and Modulating Neurophysiology of Patients With Alzheimer's Disease: a Triple Blind Randomized Sham-controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Gamma brain activity is crucial for cognitive function and intra-brain communication. Gamma frequency stimulation via transcranial alternating current stimulation(tACS) might alleviate memory deficits on both animal models of Alzheimer's disease (AD) and clinical trial. The study aims to assess the safety and efficacy of tACS on cognitive function and modulating neurophysiology in patients with AD.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Maximum Age: 90
Healthy Volunteers: f
View:
• aged 60- to 90-year-old
• clinical dementia rating scale (CDR) of 1 or mini-mental state examination (MMSE) score of 18 to 26.
• Participants were allowed to maintain their anti-dementia medications without changes from at 3 months before and throughout the study.
Locations
Other Locations
Taiwan
Department of Psychiatry, Kaohsiung Veterans General Hospital
RECRUITING
Kaohsiung City
Contact Information
Primary
Che-Sheng Chu
cschu@vghks.gov.tw
07-3422121
Time Frame
Start Date: 2023-09-01
Estimated Completion Date: 2025-07-31
Participants
Target number of participants: 48
Treatments
Active_comparator: active tACS
40 mins tACS for 10 consecutive daily sessions
Sham_comparator: sham tACS
40 mins sham tACS for 10 consecutive daily sessions
Related Therapeutic Areas
Sponsors
Leads: Che-Sheng Chu